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Issue Info: 
  • Year: 

    2014
  • Volume: 

    22
Measures: 
  • Views: 

    150
  • Downloads: 

    58
Abstract: 

MOLECULAR imprinted polymer (MIP) TECHNIQUES HAVE BEEN INCREASINGLY USED IN A VARIETY OF FIELDS INCLUDING SOLID-PHASE EXTRACTION [1], SENSORS [2], CHROMATOGRAPHY [3], PURIFICATION, DRUG DELIVERY AND CATALYSTS, ETC. IN THE PRESENT WORK, WE REPORTED AN EFFECTIVE METHOD FOR THE PREPARATION OF Molecularly imprinted polymer (MIP) NANOPARTICLES WITH GLUCOSE AS THE TEMPLATE.ADSORPTION EXPERIMENTAL RESULTS SHOWED THAT MIP-NPS WITH A SIZE OF 33.5 NM HAD GOOD SELECTIVITY TO GLUCOSE.MIPS HAVE BEEN CHARACTERIZED BY FOURIER TRANSFORM INFRARED SPECTROSCOPY (FT-IR), AND SCANNING ELECTRON MICROSCOPY (SEM).

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Writer: 

NAJAFI MOSTAFA

Issue Info: 
  • Year: 

    2012
  • Volume: 

    10
Measures: 
  • Views: 

    154
  • Downloads: 

    89
Keywords: 
Abstract: 

THE CAPACITIVE SENSING METHOD HAS RECENTLY GAINED CONSIDERABLE INTEREST BECAUSE IT PROVIDES SENSITIVE, SIMPLE AND INEXPENSIVE DETECTION OF ANALYTE-RECEPTOR BINDING WITHOUT THE NEED TO USE ADDITIONAL REAGENTS OR LABELS. THE COMBINATION OF Molecularly imprinted polymer (MIP) AND CAPACITIVE TRANSDUCTION HAVE SOME UNIQUE ADVANTAGES, SUCH AS HIGH SENSITIVITY, LABEL-FREE AND REALTIME MONITORING. IN THIS LECTURE, A BRIEF DESCRIPTION OF MOLECULAR IMPRINTING AND ITS APPLICATIONS IN ELECTROCHEMICAL SENSORS WILL BE PRESENTED; THEN, THE PRINCIPLE OF CAPACITIVE DETECTION WILL BE DESCRIBED. AT THE END, A FEW RECENTLY PUBLISHED PAPERS ON CAPACITIVE CHEMICAL SENSORS BASED ON ELECTROpolymerIZED Molecularly imprinted polymer WILL BE INVESTIGATED.

Yearly Impact:   مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Author(s): 

Issue Info: 
  • Year: 

    2024
  • Volume: 

    818
  • Issue: 

    4
  • Pages: 

    147-154
Measures: 
  • Citations: 

    1
  • Views: 

    17
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Writer: 

MOBRAM MINA

Issue Info: 
  • Year: 

    2016
  • Volume: 

    3
Measures: 
  • Views: 

    128
  • Downloads: 

    66
Abstract: 

IN PRESENT STUDY SENSING BEHAVIOR OF MOLECULAR IMPRINTING polymer (MIP) BASED ON POLYANILINE AS A MONOMER IN CONTRAST WITH AGRONOMY FUNGICIDES AS LIKE AS CARBENDAZIM AND TIOPHANATE METHYL AS A SAMPLE VIA MEASURMENT OF ELECTRICAL CONDUCTIVITY BY USING A FOUR-PROBE METHOD WAS INVESTIGATED. MOLECULAR IMPRINTING HAS PROVED TO BE AN EFFECTIVE TECHNIQUE FOR THE CREATION OF RECOGNITION SITES ON A polymer SCAFFOLD. POLYANILINE AS A CONDUCTIVE polymer HAS BEEN USED IN MANY APPLICATION LIKE CONDUCTING DYES, CHEMICAL AND GAS SENSORS AND IT IS ONE OF THE BEST CHOICES FOR THIS TECHNIQUE. Molecularly imprinted polymerS (MIPS) ARE SYNTHETIC MATERIALS THAT MIMIC ANTIBODIES AND WIDELY USED IN PHARMACEUTICAL, MEDICAL AND CHEMICAL APPLICATIONS SUCH AS CHEMICAL SENSORS. ANALYTE CONCENTRATION AND polymer RESPONSE TIME ARE THE SENSING PROPERTIES STUDIED IN THIS WORK. THE SELECTIVITY OF MOLECULAR IMPRINTING polymer AS COMPARED WITH THOSE OF ANALYTE MOLECULAR WITH SIMILAR STRUCTURE WAS INVESTIGATED. IN ALL CASES, THE CONDUCTIVITY OF MOLECULAR IMPRINTING polymer IN COMPARISON WITH THE MOLECULAR NON-IMPRINTING polymer (NIP) WAS NOTICEABLE. THIS IS DUE TO ANALYTE EFFECT ON polymer STRUCTURE.

Yearly Impact:   مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2024
  • Volume: 

    11
  • Issue: 

    2
  • Pages: 

    123-132
Measures: 
  • Citations: 

    0
  • Views: 

    8
  • Downloads: 

    0
Abstract: 

The Molecularly imprinted polymer (MIP) sensor for the rapid and immediate detection of carbidopa (CD) has been investigated. Additionally, a voltammetric sensor based on MIP with a glassy carbon electrode (MIP/GCE) has been developed for CD detection. Under optimal conditions, we observed a strong linear correlation between the sensor's peak current and CD concentrations ranging from 1.0 to 1000.0 μM, with a low limit of detection (LOD) of 0.3 μM (S/N = 3). The modified electrode demonstrated satisfactory electrocatalytic properties for CD oxidation, allowing the sensor to selectively detect CD even in the presence of high concentrations of similar compounds. Furthermore, it was confirmed that MIP/GCE effectively detected CD in urine samples.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2013
  • Volume: 

    20
Measures: 
  • Views: 

    117
  • Downloads: 

    49
Keywords: 
Abstract: 

MOLECULAR IMPRINTING IS AN EFFICIENT PROCESS FOR SYNTHESIZING NANOPARTICLE polymerIC MATERIALS THAT EXHIBIT A HIGH EFFICIENCY FOR DRUG DELIVERY SYSTEM (DDS) AND SELECTIVITY TOWARD A PARTICULAR TARGET COMPOUND.polymer SYSTEMS THAT ALLOW THE CONTROLLED RELEASE OF A DRUG ARE WELL ESTABLISHED. IN MOST...

Yearly Impact:   مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2024
  • Volume: 

    11
  • Issue: 

    4
  • Pages: 

    387-394
Measures: 
  • Citations: 

    0
  • Views: 

    8
  • Downloads: 

    0
Abstract: 

In this research, for the first time, a novel electrochemical sensor was proposed for detection of Gefitinib (Gefi) as an anticancer drug based on a Molecularly imprinted polymer (MIP) on the glassy carbon electrode (GCE) surface. The present research aimed to introduce a selective electrochemical sensor through electropolymerization of o-aminophenol (o-AP) as monomer on the GCE surface for the determination of Gefi as a template molecule. Afterwards, the proposed sensor was assayed by scanning electron microscopy (SEM), fourier-transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), and electrochemical methods including electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The introduced sensor illustrated a good linear range of 5 to 1000 µM and limit of detection of 1.6 µM for Gefi detection. Moreover, the modified electrode to determine Gefi in the blood serum sample was successfully employed. The recoveries were from 98.8 to 100.5% and the RSD was less than 2.7% which illustrated the applicability of proposed sensor in the real sample.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2019
  • Volume: 

    30
  • Issue: 

    6
  • Pages: 

    454-461
Measures: 
  • Citations: 

    0
  • Views: 

    195
  • Downloads: 

    0
Abstract: 

Background & Aims: In this study, a magnetic molecular imprinted polymer was used to measure the diltiazem drug. Based on the structure and pharmaceutical agent group, methacrylic acid was selected as a monomer for Diltiazem. Ethylene glycol de-methacrylate and azobisisobutyronitrile were used as cross-linkers and polymerisation initiators, respectively. Also, chloroform was used as a porogenic solvent. In order to investigate the polymer absorption capacity, a high-performance liquid chromatography system was used which had an absorption capacity of 9. 59 mg / g. This allows the measurement and analysis of this drug in biological fluids and separates them from various wastewater. Materials & Methods: Methacrylic acid (MAA), ethylene glycol de-methacrylic acid (EGDMA), and azobisisobutyronitrile (AIBN) were obtained from Sigma Aldrich while Diltiazem was obtained from Sobhan-Dar Company. Serum samples were prepared from the medical diagnostic laboratory in Urmia. High-performance liquid chromatography with UV detector was used to determine the concentration of drug in existing samples by experimental method. Results: The results indicate that this drug is well absorbed by the synthetic polymer, and shows the results of repeated etiology and re-use of this polymer for the drug. It is possible to use this polymer for 5-6 times and it has a capacity of 9. 50 mg / g of drug per gram of polymer. Conclusion: polymer molecular membrane can act as a good absorbent for absorbing and measuring this drug with respect to the structure of the drug. Therefore, methacrylic acid has been used as polymerization monomer and has shown good results for drug absorption.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2024
  • Volume: 

    11
  • Issue: 

    1
  • Pages: 

    31-39
Measures: 
  • Citations: 

    0
  • Views: 

    5
  • Downloads: 

    0
Abstract: 

The combination of aptamer is performed with Molecularly imprinted (MIP) using their unique features. In this sense, first the screen-printed carbon electrode (SPCE) was modified with nano size iridium cupper on nitrogen-doped carbon nanocapsoul (CN@IrCu) and, then, the Aptamer -MIP hybrid was used to detect Helicobacter pylori. This design leads to the use of dual properties of Aptamer and MIP. Moreover, CN@IrCu has been used as a substrate to increase aptamer loading and the conductivity. The sensing surface fabrication steps was measured by several different electrochemical techniques such as cyclic voltammetric (CV), differential pulse voltammetric (DPV), electrochemical impedance spectroscopy (EIS). The sensor shows a linear range from 102 CFU.ml-1 to 107 CFU.ml-1 with a detection limit of 33 CFU.ml-1. This Aptamer-MIP/CN@IrCu/SPCE was successfully evaluated in determining the concentration of Helicobacter pylori in blood serum samples with high reproducibility and selectivity. This MIP-aptasensor is low cost, low response time, high stability and good sensitivity.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2015
  • Volume: 

    7
Measures: 
  • Views: 

    236
  • Downloads: 

    69
Abstract: 

THERE IS AN EVER-INCREASING NEED FOR THE DEVELOPMENT OF FAST AND SENSITIVE DIAGNOSTIC TOOLS FOR SCREENING OF FOOD COLORANTS BECAUSE OF THEIR ADVERSE HEALTH EFFECTS SUCH AS ALLERGY, THYROID TUMOURS, CHROMOSOMAL DAMAGE, URTICARIA AND HYPERACTIVITY. Molecularly imprinted polymer (MIP) SENSORS HAVE BEEN CONSIDERED AS PROMISING NOVEL TOOLS FOR SELECTIVE AND SENSITIVE DETECTION OF FOOD COLORANTS. HOWEVER, OPTIMIZING OF THE SENSOR SHOULD BE CONSIDERED TO ACHIEVE HIGH SENSITIVITY, LOWER DETECTION LIMIT, MORE CHEMICAL AND MECHANICAL STABILITY AND LESS DETECTION TIME. IN THIS WORK AN ELECTRO-polymerIZED MIP SENSOR FOR SUNSET YELLOW (SY) DETECTION, AN IMPORTANT FOOD COLORANT, WAS FABRICATED AND EFFECTIVE PARAMETERS WERE OPTIMIZED USING ELECTROCHEMICAL METHODS. THE VALUE OF THE FOOD COLORANT DETECTION SIGNAL WAS ABOUT 1500–FOLD HIGHER USING FUNCTIONALIZED CARBON NANOTUBE DEPOSITED ON GLASSY CARBON ELECTRODE AND CHEMICAL STABILITY OF THE MODIFIED ELECTRODE WAS INCREASED USING NAFION. IT WAS OBSERVED THAT A FAST POTENTIAL SCAN SPEED AND FEWER CYCLIC VOLTAMMETRY (CV) CYCLES OF ELECTRO polymerIZATION CAUSED A ROUGH AND POORLY imprinted polymer. HENCE, OPTIMIZATION OF THE CV CYCLES NUMBER, AND POTENTIAL SCAN SPEED ARE ESSENTIAL FOR THE EFFECTIVENESS OF THE imprinted MEMBRANE. MOREOVER THE IMMERSING TIME, BUFFER SOLUTION OF SYNTHESIS AND IMMERSING STEPS, CONVENIENT PH AND MONOMER/CROSS LINKER RATIO WERE OPTIMIZED. THE MENTIONED SENSOR WAS SUCCESSFULLY APPLIED TO DETERMINATION OF SY IN BEVERAGES, MEDICINES, CANDIES, JELLY POWDER, FRUIT DRINKS AND CHOCOLATES COLORFUL COVER, AND SATISFACTORY RESULTS WERE OBTAINED. THE PROPOSED SENSOR DEMONSTRATES HIGH SELECTIVITY, CHEMICAL STABILITY, ACCEPTABLE REPRODUCIBILITY, AND COULD BE EXTENDED TO RECOGNIZE OTHER FOOD ADDITIVES.

Yearly Impact:   مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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